Too much Acyclovir (antiviral drug)

Acyclovir (a.k.a., Aciclovir), is an antiviral agent marketed under trade names such as Acivirax, Zovirax, Zoral, Cyclovir, Xovir and Imavir, Herpex and Acivir. Currently it is the most prescribed antiviral drug primarily used for a herpes family of infections such as

  • Cold sores – Herpes simplex virus type I (HSV-1)
  • Genital herpes – Herpes simplex virus type II (HSV-2)
  • Chicken pox and shingles – Varicella zoster virus (VZV)
  • Infectious Mononucleosis (Mono) – Epstein-Barr virus (EBV)
  • Viral illness – Cytomegalovirus (CMV) – least activity

The drug is also used for prophylaxis against herpes family viruses in immunocompromised patients (such as patients undergoing cancer chemotherapy). The half-life of aciclovir is approximately 2.5-4 hours. It is eliminated renally. Therefore, in order for the medication being effective, it has to be taken every few hours to sustain its concentration in the blood stream.

Drug resistance to acyclovir is rare if used short term in aggressive therapy approach. However, in immune-compromised people, continuous use of the drug can lead to development of a viral resistance (viral mutation), significantly decreasing the effectiveness of the agent. Once the drug resistance is developed, it would also reduce the effectiveness of other antiviral drugs such as valaciclovir and famciclovir.

Too much acyclovir toxicity can lead to adverse health conditions

Alghough Acyclovir is considered a narrow range antiviral agent and presents a relatively low cytotoxicity, it negatively and aggressively affects the state of biological equilibrium in a living organism. Some of the well documented side effects and symptoms of acyclovir are

  • Agitation
  • Vertigo
  • Confusion
  • Dizziness
  • Oedema
  • Arthralgia
  • Sore throat
  • Constipation
  • Abdominal pain
  • Hair loss
  • Rashes
  • Fatigue
  • Coma
  • Seizures
  • nutropenia
  • Leukopenia
  • Crystalluria
  • Anorexia
  • Hepatitis
  • Anaphylaxis

The drug’s toxicity should be considered in all patients where any organs have an impaired function, especially liver or kidneys. Many patients report kidney pain with using of acyclovir. If any kidney discomfort continues with usage of the drug, it should be immediately discontinued. If a long term acyclovir administration is warranted, the agent’s blood plasma concentrations should be measured regularly to avoid severe intoxication, especially in patients with renal dysfunctions.

Common Acyclovir adverse effects and symptoms reported by patients are

  • Headaches and migraines 6 to 8 hours after intake
  • Change in urine odor
  • Extreme fatigue and feeling tired all the time
  • Reduced recovery from injuries
  • Gastrointestinal problems that continue past the treatment, including pale stools
  • Insomnia and alteration of sleep patterns
  • Muscle cramps and pain
  • Electrolyte imbalances
  • Vomiting and nausea
  • Joint pain
  • Mood swings and depression
  • Bad taste in mouth
  • Drowsiness
  • Increase of acne breakouts
  • Increased thirst
  • Facial swelling
  • Low back and kidney pain
  • Numbness in feet and hands
  • Hair loss
  • Liver function impairment, yellow eyes
  • Light sensitivity

When using the drug, it is advised to reduce dietary calcium as it alters calcium metabolism and drink plenty of water to reduce the strain on the kidneys.

Acyclovir should only be used as a last measure of the viral control if other methods are not effective. Other methods of viral control are low carbohydrate diet, restoration of the digestive function, particularly protein absorption with protease enzymes, restoration of the intestinal flora particularly with acidophilus probiotics, reduction of stress, staying warm, dietary avoidance of coffee, beverages that contain citric acid, arginine rich foods, and raising body alkalinity with foods and especially with consumption of lemons. Supplementation of L-Lysine amino acid at 250-500mg daily in mornings for a couple of weeks can be helpful. Higher doses of L-Lysine are damaging to kidney functions. Immunomodulatory herbs such as andrographis paniculata can be very helpful short term as well.